Fig. 8: Response of force and calcium to CPA and SEA0400. | Communications Biology

Fig. 8: Response of force and calcium to CPA and SEA0400.

From: Synchronous force and Ca2+ measurements for repeated characterization of excitation-contraction coupling in human myocardium

Fig. 8

a Normalized average contraction force and calcium and force-calcium loops of human myocardial slices in the presence of DMSO (0.1%, n = 4 patients, 4 slices), or CPA and SEA0400 (25 µM, 25 µM, n = 4 patients, 4 slices) at 0.5 Hz pacing frequency. b Relative changes of amplitude, Ton, and tau in force and calcium transients of myocardial slices after treatment with DMSO, or CPA and SEA0400 (amplitude, n = 4 patients, 4 slices; Ton and tau, n = 5 patients, 5 slices in force and calcium, respectively). Data are depicted as means ± SEM. Statistical differences were calculated with paired Student t-test with a significance cutoff of p < 0.05.

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