Fig. 3: Presentation of MR1 ligands delivered on soluble MR1 molecules requires cellular MR1. | Communications Biology

Fig. 3: Presentation of MR1 ligands delivered on soluble MR1 molecules requires cellular MR1.

From: Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation

Fig. 3

a MR1T cell clone (1e3 cells) IFN-γ response to BEAS-2B, BEAS-2B MR1-/- and BEAS-2B MR1-/- : MR1A (1e4 cells) incubated with MR1/5-OP-RU or MR1/6-FP monomers. Also included MR1T clone IFN-γ response to MR1/5-OP-RU monomer only with no antigen presenting cells. b Same as (a), except the antigen presenting cells are THP-1, THP-1 MR1-/- and THP-1 MR1-/- : MR1A (1e4 cells). Data are representative of n = 2 independent experiments. Technical duplicates within the representative experiment are shown with a line connecting the mean.

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