Fig. 7: IsknvDNMT has the ability to de novo methylate DNA similar to DNMT3. | Communications Biology

Fig. 7: IsknvDNMT has the ability to de novo methylate DNA similar to DNMT3.

From: Hypermethylated genome of a fish vertebrate iridovirus ISKNV plays important roles in viral infection

Fig. 7

a Protein structure partitioning and motif identification in the DNA methylation catalytic domain for isknvDNMT and scDNMTs. Red, yellow, green, blue, purple, and orange represent motifs I, IV, VI, VIII, IX, and X, respectively. b Protein structure prediction and protein structure alignment for isknvDNMT and scDNMTs. c Phylogenetic trees based on isknvDNMT, scDNMTs, and other iridovirus DNMT proteins. d pMD19-isknvMCP was cotransfected into HEK293T cells with pCMV-isknvDNMT-Myc, pCMV-EGFP-Myc, or pCMV-Myc, and the methylation level of pMD19-isknvMCP was measured by MSP at 48 h. In the figure, “M Primers” indicates methylated primers, and “U Primers” indicates unmethylated primers.

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