Fig. 6: In vitro platelet activation by the immune complexes assembled on SCs. | Communications Biology

Fig. 6: In vitro platelet activation by the immune complexes assembled on SCs.

From: Molecular architecture and platelet-activating properties of small immune complexes assembled on heparin and platelet factor 4

Fig. 6

SRA data showing the platelet activation by KKO incubated with a UFH/PF4 mixture without fractionation of the immune complexes (blue bars), and after isolating fractions containing two and one KKO molecules per immune complex (fractions A and B represented with the violet and purple bars, respectively); platelet activation is shown as the percent release of 14C-serotonin. The left and right bars in each group represent the data acquired with recombinant and platelet-derived forms of PF4, respectively. The control measurements are shown with the black and gray bars (KKO alone and KKO/heparin mixture, respectively). The chromatogram in the inset (blue trace) shows the elution windows during which the two fractions (A and B) were collected; the reference chromatograms of the free KKO (black) and the starting UFH/PF4 mixture (red) are shown.

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