Fig. 9: DYRK1A and STAT3 signaling pathway changes in diabetes mice and human skin wounds. | Communications Biology

Fig. 9: DYRK1A and STAT3 signaling pathway changes in diabetes mice and human skin wounds.

From: MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes

Fig. 9

a Summary data showing relative mRNA expression levels of DYRK1A in normal and diabetic mice (n = 7–8). b, c Representative images and summary data showing protein expression levels of DYRK1A, phosphorylated (p)-STAT3 (Tyr705), p-STAT3 (Ser727), and total STAT3 in normal and diabetic mice (n = 5). d, e Representative images and summary data showing expression levels of DYRK1A, phosphorylated (p)-STAT3 (Tyr705), p-STAT3 (Ser727), and total STAT3 in skin wound tissues of acute wound and DFU. DFU, Diabetes foot ulcer. Vertically stacked strips of bands in a figure are not derived from the same membrane in any case. Data are presented as mean ± SEM (n = 5), *P < 0.05, **P < 0.01, ***P < 0.001.

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