Fig. 4: Integrated molecular features and pathways distinguishing the TNBC lines.
From: One-pot method for preparing DNA, RNA, and protein for multiomics analysis
The mixOmics R package was used to integrate the molecular features resulting from transcriptomics and proteomics analyses. The first (a) and second (b) principal components of the integration are shown. c The MOGSA R package was used to identify hallmark pathways significantly enriched or decreased as indicated by the transcriptomics and proteomics data. d Decomposition of the hypoxia (top) and mTOR (bottom) pathways to show the contribution of molecules within these pathways to the overall variance in the noted gene sets (PMID: 31243065).
