Fig. 3: Common and specific ICP-related lncRNAs exhibited diverse immune regulation patterns. | Communications Biology

Fig. 3: Common and specific ICP-related lncRNAs exhibited diverse immune regulation patterns.

From: The landscape of immune checkpoint-related long non-coding RNAs core regulatory circuitry reveals implications for immunoregulation and immunotherapy responses

Fig. 3

a The upper triangular matrix shows the number of shared lncRNA-ICP gene pairs between any two cancers. The lower triangular matrix shows the number of shared ICP-related lncRNAs. A Venn diagram represents the overlap of lncRNA-ICP gene pairs as well as ICP-related lncRNAs in two lung cancer subtypes, LUAD and LUSC. The hypergeometric test was used to assess the significance of the overlap, and the p values are shown below the figure. b Common lncRNA network. The blue and red nodes indicate the ICP and common lncRNAs, respectively. Pie charts of different colors indicate the presence of genes in different cancers. The size of the nodes indicates the number of connected nodes. The thickness of the edges indicates the level of correlation. c Patterns and numbers of regulated immune genes among the pattern-variable lncRNA-ICP gene pairs in different cancers. The pie chart represents the percentages of the four models. The heatmap represents the number of immune genes. d Inferred mechanisms by which ICP-LncCRCTs act between immune cells and tumor cells. e Stacked bars indicate the number of common lncRNAs and specific lncRNAs in each cancer. f Cancer samples were clustered by t-distributed stochastic neighbor embedding (t-SNE) based on specific lncRNAs. Different colors represent different cancer types.

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