Fig. 2: Ischemic stroke leads to increased ubiquitination of 198 proteins with the highest expression levels in glutamatergic neurons. | Communications Biology

Fig. 2: Ischemic stroke leads to increased ubiquitination of 198 proteins with the highest expression levels in glutamatergic neurons.

From: Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases

Fig. 2

a Volcano plots showing proteins with significantly changed ubiquitination in contralateral vs. sham groups (left panel) and ipsilateral vs. sham and contralateral control groups (right panel). Red circles indicate proteins with downregulated, blue circles with upregulated, and gray circles with not significantly changed ubiquitination. Data were pooled from 2 to 3 MS experiments. Significance at fold change = 2 with P < 0.05 (two-tailed unpaired t-test). b Heatmap showing the mean RNA expression levels (ln) of all proteins with increased or decreased post-ischemic ubiquitination in different brain cells in the frontal cortex. Single-cell mRNA expression levels were derived from the publicly available database Dropviz27. Ub ubiquitination.

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