Fig. 2: Telomeric RNA (TERRA) sequence motif abundance increases in Earth-based high-altitude climbers of Mt. Everest.
From: Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing
Relative abundances of motifs highly correlating to the canonical TERRA motif 5´-UUAGGG-3´ in RNA-Seq data from a longitudinal study of two male climbers of Mt. Everest (1, 2) who experienced telomere elongation and evidence of ALT-like activity during the expedition. Triangular matrices display pairwise Mann–Whitney U test p-values (FDR-adjusted) for comparisons between the groups, with each box containing a p-value connecting to the groups in the comparison; significance (p < 0.05) is indicated in red (Supplementary Data 4). Results demonstrate TERRA overexpression at high altitudes (EB, CII) compared to lower altitudes (CO, NP) in this somewhat similar stressful and high-altitude extreme environment, independent of microgravity.
