Fig. 3: Humoral factors from ECs of different origins.
From: Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model
a Quantitative reverse transcription PCR analysis of neurotrophic and neuroprotective factors (BDNF, NGF, NT3, NT4, EGF, FGF2, HGF, IGF-1, neuropilin-1, and PDGF-B) in ECs from brain, liver, and fat (n = 3 per group). The gene expression of factors is relative to that of brain-derived ECs, which is set to 1. Data are presented as mean ± SEM. b Quantitative reverse transcription PCR analysis for angiogenesis-related factors (VEGF-A and VEGFR-2) in ECs from brain, liver, and fat (n = 3 per group). The gene expression of factors is relative to that of brain-derived ECs, which is set to 1. Data are presented as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns not significant. BDFN brain-derived neurotrophic factor, EC endothelial cell, EGF epidermal growth factor, FGF2 fibroblast growth factor 2, HGF hepatocyte growth factor, IGF-1 insulin-like growth factor-1, NGF nerve growth factor, NT neurotrophin, PDGF-B platelet-derived growth factor-B, VEGF vascular endothelial growth factor, VEGFR vascular endothelial growth factor receptor.
