Fig. 3: Differential expression of mRNAs in Gtl2 polyA knock-in placentas at E12.5. | Communications Biology

Fig. 3: Differential expression of mRNAs in Gtl2 polyA knock-in placentas at E12.5.

From: Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature

Fig. 3

a–c Volcano plots showing differentially expressed mRNAs (DEGs) in PKI, MKI, and HOMO compared to WT. The DEGs labeled in red are located in Dlk1-Dio3 domain. The DEGs with significant changes and labeled in black are verified by qRT-PCR. d, e Venn diagrams of upregulated and downregulated DEGs in PKI, MKI and HOMO placentas, respectively. f The KEGG enrichment terms of upregulated DEGs are significant in MKI and HOMO, and not significant in PKI. The red dashed line represents the p is 0.05. g The top 10 GO enrichment terms of MKI and HOMO overlapped upregulated DEGs. Terms in red related to MKI and HOMO phenotypes. h The top 10 KEGG enrichment terms of MKI and HOMO overlapped upregulated DEGs. Terms in red related to MKI and HOMO phenotypes.

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