Fig. 7: A schematic illustrating the changes in Gtl2 polyA knock-in placentas in this study. | Communications Biology

Fig. 7: A schematic illustrating the changes in Gtl2 polyA knock-in placentas in this study.

From: Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature

Fig. 7

PloyA signal is inserted into Gtl2. PKI placenta shows the similar phenotypes in placental morphology with WT, and Dlk1-Dio3 imprinted domain works normally. MKI and HOMO placentas show the similar phenotypes, with expanded junctional zones and reduced labyrinth areas. Fetal blood spaces are reduced, and maternal blood spaces are larger in the labyrinth. Then, the DNA methylation and imprinted status are affected, leading to gene expression disregulated in the Dlk1-Dio3 domain.

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