Fig. 6: Model proposing how elevated GC alters the trajectory of hypothalamic development and function.
From: Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish
In our model of elevated GC, we suggest that in the short-term, GC exposure drives adaptive plasticity, whereby we observed precocious hypothalamic development. In the long-term, chronic GC exposure leads to an accumulation of allostatic load, leading to allostatic overload. We observed this via failed hypothalamic maturation during the larval stage, and subsequent early physical decline of exposed fish.
