Fig. 5: Meta-analysis with public databases supports the iPSC dynamic network.

A dynamic molecular network was generated by iMAD analysis using publicly available RNA-seq data of cerebellar tissues from Atxn1-KI or Atxn1-Tg mice, and then connected with the dynamic molecular network of iPSCs (Fig. 4c) (upper row). Before the connection, the similarity of the connection characteristics of the Atxn1-KI and Atxn1-Tg mouse networks with the iPSC network was preliminarily examined (Supplementary Fig. 8). The connected dynamic network from human iPSCs to cerebellar tissues of the two SCA1 mouse models (middle row network) included the ISG15-related sub-network, as shown in concentric circle diagrams (purple letters and purple lines). Detailed data are also shown in Supplementary Figs. 6 and 7.