Fig. 6: Schematic model of TrSAM-mediated regulatory mechanism during carbon catabolite repression in T. reesei. | Communications Biology

Fig. 6: Schematic model of TrSAM-mediated regulatory mechanism during carbon catabolite repression in T. reesei.

From: The protein methyltransferase TrSAM inhibits cellulase gene expression by interacting with the negative regulator ACE1 in Trichoderma reesei

Fig. 6

The putative methyltransferase TrSAM interacts with the transcription repressor ACE1 and methylates it at potential methylation site R383 in glucose medium, which activates ACE1 to compete with XYR1 for binding cellulase genes promoter thus results in CCR (left panel). When ACE1 R383 residue is mutated to glutamine (middle panel) or TrSAM is knocked out (right panel), ACE1 is inactivated which led to impaired DNA binding ability and thus relieves CCR under repressing condition in T. reesei.

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