Fig. 5: miR-515-5p directly targeted ITGA8 in ovarian cancer. | Communications Biology

Fig. 5: miR-515-5p directly targeted ITGA8 in ovarian cancer.

From: M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer

Fig. 5

a The binding site for hsa-miR- 515-5p in the 3′ UTR of ITGA8. b RT-qPCR analysis of ITGA8 in patient tissues. c, d Pearson correlation analysis of ITGA8 and miR-515-5p or circTMCO3 in the tumor group. e RT-qPCR analysis of ITGA8 in A2780 and SKOV3 cells in coculture assays (n = 3). f The expression of miR-515-5p and ITGA8 in A2780 and SKOV3 cells transfected with miR-515-5p mimics, inhibitor, or negative controls (mimics and inhibitor NC) was determined via RT-qPCR (n = 3). g Luciferase activity of wildtype (ITGA8-WT) or mutant (ITGA8-MUT) ITGA8 reporters (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001. Data were presented as mean ± standard deviation.

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