Fig. 8: M2 macrophage-derived exosomal circTMCO3 accelerated ovarian cancer progression.
Mice were intraperitoneally injected with 5 × 106 SKOV3 cells and administrated with control (PBS), Exo, Exo-shNC, Exo-shcircTMCO3#1 or Exo-shcircTMCO3#2. a Mouse abdomen was opened and imaged. b Tumor nodules were counted (n = 5). c Tumor weight (n = 5). d–f RT-qPCR analysis of circTMCO3, miR-515-5p and ITGA8 in tumors (n = 5). g IHC staining of Ki67 and ITGA8 in tumors. Scale bar: 100 μm. h Protein levels of ITGA8, MMP9, E-cadherin, Vimentin and Snail in tumors were examined by Western blotting. **P < 0.01 and ***P < 0.001. Data were presented as mean ± standard deviation.
