Table 1 Effect of peptide V11A on the growth of diverse clinical S. pneumoniae strains and other bacterial species

From: Klebsiella pneumoniae peptide hijacks a Streptococcus pneumoniae permease to subvert pneumococcal growth and colonization

Species

Strain

Serotype

MIC50 V11A (mg/ml)

S. pneumoniae

106.66 (Swiss)

6B

0.125

S. pneumoniae

110.58 (Swiss)

Non-typeable

0.5

S. pneumoniae

1154.75 (Swiss)

23F

0.5

S. pneumoniae

1186.70 (Swiss)

9N

0.062

S. pneumoniae

1188.31 (Swiss)

8

0.125

S. pneumoniae

1189.53 (Swiss)

19A

0.031

S. pneumoniae

1189.65 (Swiss)

3

0.125

S. pneumoniae

1193.68 (Swiss)

12F

0.25

S. pneumoniae

208.41 (Swiss)

7F

0.25

S. pneumoniae

ATCC 17619 (South Africa 19A-7)

19A

X

S. pneumoniae

ATCC 700903 (43362 Finland)

6B

0.125

S. pneumoniae

D39

2

0.125

S. pneumoniae

R6

Non-typeable

X

S. mitis

3308.46

n.a.

X

S. pseudopneumoniae

410.05

n.a.

0.031

S. aureus

ATCC 29213

n.a.

X

H. influenzae

ATCC 49247

n.a.

X

K. pneumoniae

ATCC BAA-1706

n.a.

X

  1. MIC50 (minimum inhibitory concentration inhibiting at least 50% of bacteria growth) for Swiss clinical S. pneumoniae isolates and reference strains, including tetracycline-resistant strain ATCC 700903 with intermediate resistance to penicillin (MIC 1 µg/ml), sulfamethoxazole/trimethoprim-resistant strain 1154.75, erythromycin-resistant strain 106.66 and other bacterial species of the nasopharyngeal microbiota was calculated from data shown in Fig. 1a for D39, Fig. 1c for 1154.75 or Supplementary Fig. 1 for all other strains. “X” indicates a lack of inhibition and “n.a.” not applicable.
Back to article page