Fig. 2: Specific ablation of podocyte ROCK2 prevents FSGS progression in mice. | Communications Biology

Fig. 2: Specific ablation of podocyte ROCK2 prevents FSGS progression in mice.

From: Deletion of podocyte Rho-associated, coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis

Fig. 2

a The scheme of the strategy for the generation of ADR mice. b Serum creatinine (Cr) levels at 12 weeks of age (n = 6, 7). c Urinary albumin to creatinine ratio (ACR) in ADR-injected mice (n = 7). d Representative periodic acid-Schiff (PAS)-stained images of kidney glomeruli from mice. The scale bar on the top left represents 10 μm (n = 6). e Wilms tumor 1 (WT1) immunostaining and quantification of WT1-positive cells in glomeruli from mice. The scale bar on the top left represents 10 μm (n = 3). f Foot process width examined by transmission electron microscopy (TEM). The scale bar on the top left represents 1 μm (n = 3). g GBM thickness assessed by TEM. The scale bar on the top left represents 0.5 μm (n = 3). h Masson’s trichrome-stained kidney sections. The scale bar on the top left represents 100 μm. Fibrosis volume was quantified as the area stained positive for collagen. i The expression levels of fibrosis mediators in the kidney (n = 4). *p < 0.05. Data represent the mean ± s.e.m.

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