Fig. 7: Schematic diagram of the evolution of the bile infarct in liver acini of the classic hepatic lobules (hexagonal structure). | Communications Biology

Fig. 7: Schematic diagram of the evolution of the bile infarct in liver acini of the classic hepatic lobules (hexagonal structure).

From: Multiscale X-ray phase-contrast CT unveils the evolution of bile infarct in obstructive biliary disease

Fig. 7

After BDL, the infarcts occur from the 1st day of BDL, and their volume and number increase remarkably with time after BDL. Moreover, the infarcts develop from zone I to zone III in the 3D acinus model during the disease progression. The bile infarct-sinusoidal microchannels emerge with the infarcts, and their diameter up to 3.5 µm means bile acids and other toxic compounds could directly leak from the infarcts into the hepatic sinusoids. Additionally, the microchannels gradually spread throughout the liver as the infarcts evolve in the progression of the disease. The diagram was created using Adobe Illustrator 2020 (Adobe, San Jose, CA).

Back to article page