Fig. 7: Model of CaSR activation.
From: Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges
The cartoons highlight the role of inter-subunit disulfide bonds in negatively regulating CaSR activity and limiting its constitutive activity. Compared with WT, the inter-subunit disulfide bond mutants displays constitutive activity and higher potency to CaCl2.
