Fig. 3: Sequence variants that associate with ET and multiomics approaches used to uncover candidate causal genes.
From: GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis
Using multiomics approaches of the lead 12 variants, we identified 7 potential causal genes. Gray boxes indicate where data points to a candidate causal gene. Effects are shown for the minor allele. Combined Annotation Dependent Depletion (CADD)84 score estimates the deleteriousness of sequence variants. Variants are considered pathogenic if CADD > 12.37. *Secondary signal at PPARGC1A.
