Fig. 1: ADAR2 KO suppresses lipid accumulation in hepatocytes. | Communications Biology

Fig. 1: ADAR2 KO suppresses lipid accumulation in hepatocytes.

From: Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice

Fig. 1

a Western blot of ADAR2 expression in the livers of C57BL/6J mice after normal diet (ND) or high‐fat diet (HFD) consumption for 12 weeks (n = 4 mice/group). b Western blot of ADAR2 expression in Huh7 cells stimulated with palmitic acid (PA) (0.25 mM) for 24 h (n = 6, three independent experiments). c Western blot of ADAR2 expression in ADAR2-deficient Huh7 cells (n = 6, three independent experiments). d Representative Oil red O image of lipid drop accumulation in ADAR2-deficient Huh7 cells stimulated with palmitic acid (PA) (0.25 mM) for 24 h (n = 3, three independent experiments). e Western blot of de novo lipogenesis-related protein in ADAR2-deficient Huh7 cells stimulated with palmitic acid (PA) (0.25 mM) for 24 h (n = 3, three independent experiments).

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