Fig. 2: Behavior of the inferred electrophysiological quantities of interest with Aβ and tau deposition levels. | Communications Biology

Fig. 2: Behavior of the inferred electrophysiological quantities of interest with Aβ and tau deposition levels.

From: Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease

Fig. 2

From left to right: ratio of power in the theta band (4–8 Hz) of the regional excitatory input currents (the E/MEG is proportional to the excitatory input current), ratio of power in the alpha1 band (8–10 Hz) and mean excitatory firings (over all regions and time points). Each of the quantities was standardized using the mean and standard deviation from all subjects, for visualizing general trends. Participants were then grouped according to clinical diagnosis and Aβ-positivity (a) and Braak stages (b). In the box-and-whisker plot, the central lines indicate the group medians, with the bottom and top edges of each box denoting the 25th and 75th percentiles, respectively. Whiskers extend to the maximum and minimum values while data points that are deemed outliers for the group are plotted individually with circles. The results of ANCOVA post-hoc t-tests for the above-mentioned groups, with the corresponding electrophysiological quantity as response variable and age and sex as covariates are also shown. * represents significance level p < 0.05, ** means significance level p < 0.01 and *** is p < 0.001.

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