Fig. 3: Neuronal excitabilities under the influence of Aβ, tau and Aβ·tau. | Communications Biology

Fig. 3: Neuronal excitabilities under the influence of Aβ, tau and Aβ·tau.

From: Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease

Fig. 3

Inferred neuronal excitability values for the brain regions of interest (“y”-axis) and all subjects (“x”-axis). Participants were grouped according to clinical diagnosis and Aβ-positivity in this figure, to understand Aβ’s contribution to the individually estimated biological profiles (see Supplementary Fig. 3 for tau’s effect). Within a group, subjects appear according to their existing ordering in the anonymized database. Warm colors represent hyperexcitability of the region in the subject’s brain and cool colors denote hypoexcitable states (the color-bar extends to the extremes of the optimization interval). Results of ANCOVA post-hoc t-tests for the above-mentioned groups, with the average intra-brain excitability values as response variable and age and sex as covariates appear in the upper right. P-values in bold fonts represent differences at a 5% significance level or lower.

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