Fig. 1: Overview of DEmRNAs, and lncRNA‒miRNA‒mRNA ceRNA network of target genes, n = 3 biologically independent samples. | Communications Biology

Fig. 1: Overview of DEmRNAs, and lncRNA‒miRNA‒mRNA ceRNA network of target genes, n = 3 biologically independent samples.

From: Whole transcriptome profiling reveals a lncMDP1 that regulates myogenesis by adsorbing miR-301a-5p targeting CHAC1

Fig. 1

a Volcano plots of differentially expressed genes in the G1 and G2 groups. b Venn diagram for the comparison of G2 with D1, D2, D4, D6, and D8. Orange represents G2-vs.-D1, blue represents G2-vs.-D2, pink represents G2-vs.-D4, green represents G2-vs.-D6, yellow represents G2-vs.-D6. c Trend analysis graph of all differentially expressed mRNAs. Blue represents profile0, pink represents profile19, gray represents profile2. d WGCNA analyzed the gene expression profiles of CPMs at different developmental stages, and the expression patterns of the module genes in each sample were shown by module eigenvalues. The module eigenvalues in each sample reflect the combined expression levels of all genes in each sample. Pink represents high expression, blue represents low expression. e Venn diagrams of the four analytical methods. RNA-seq (blue) indicates the sum of differential genes for the intersection of the six different groups compared; WGCNA (yellow) indicates all genes in the six modules MM.black, MM.green, MM.magenta, MM.cyan, MM.grey60 and MM.lightgreen; STEM (pink) indicates the sum of differential genes with profile0, profile19 differential genes; maker (green) indicates the differential genes with Pearson correlation coefficient ≥ 0.95 with the expression of 14 marker genes among 6937 differential genes. f, g GO and KEGG annotations of the target gene cluster. Bubble size represents the number of differential genes enriched in GO term. Bubble color represents the significance of enrichment in GO term. The larger the value, the more significant the enrichment. Red indicates the larger the value, and blue indicates the lower the value. The color of the column indicates the enrichment significance of the Pathway. The red indicates the higher the significance, and the blue indicates the lower the significance. h The pink ellipses represent mRNA (CHAC1 is represented by red ellipse), the green triangles represent miRNA (miRNA-301a-5p is represented by red font), and the blue diamonds represent lncRNA (lncMDP1 is represented by red font).

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