Fig. 1: Modeling evoked FSCV antidepressant data.
From: Modulation of serotonin transporter expression by escitalopram under inflammation
a Schematic of experimental protocol for evoked FSCV serotonin signals in the CA2 region of the hippocampus. b Representative FSCV color plot control file. Inset: The vertical trace (i vs. v) shows a representative serotonin CV, while the horizontal trace (i vs. t) shows the release and reuptake profile of serotonin over the course of the experiment. c Experimental concentration vs. time traces from the CA2 region of the hippocampus of female mice (n = 4 animals each dose, mean ± SEM) pre- and post-escitalopram intraperitoneal administration at time and dose given in the legend. d Simulation of serotonin extracellular concentration pre- and post-escitalopram at time and dose given in the legend solely assuming competitive inhibition. e Simulation following the same protocol as in D, adding non-competitive inhibition. f Simulation following the same protocol as in E and adding SERT internalization. Illustrations made with Biorender.com.
