Fig. 4: Detailed analysis of NNCGNN flanking sequence preferences of DNMT3C.
a Comparison of the NNCGNN methylation rates of WT DNMT3C, DNMT3C C543N/V547A (NA) double mutant and WT DNMT3B. Examples of the rate fittings are shown in Supplementary Fig. 5. Shown are the 10% most preferred/disfavored sites. DNMT3B data were taken from19. b Enrichment and depletion of bases at the -2 to +2 flank of the 10% most preferred and most disfavored NNCGNN sequences. DNMT3C-specific effects at positions -2 and -1 are highlighted by arrows.
