Fig. 5: Correlation of DNMT3C flanking sequence preferences and genomic methylation.
a Correlation of the NNCGNN flanking profiles of different DNMTs with the genomic methylation of 6KO cells33. DNMT data were taken from: DNMT153, DNMT3A19,29; DNMT3B19. Shown are Pearson r values. See also Supplementary Fig. 8 and Supplementary Table 4. b Correlation of DNMT3C flanking sequence preferences and genomic methylation in o/e ratios for all 256 NNCGNN sequences. The boxes show the median, 1st and 3rd quartile. Whiskers display the 1.5 IQR distance. X indicates the average. c Enrichment and depletion of bases at the -2 to +2 flank of the 10% most highly/lowly methylated NNCGNN sequences in 6KO cells. DNMT3C-specific effects at position -2 and -1 are highlighted by arrows. d Methylation levels of NNCG sites in 6KO cells expressed as o/e. The DNMT3C-specific CC preference is highlighted by an arrow. e Local correlation analysis of methylation levels and DNMT3C NNCGNN preferences of consecutive CpG sites in chromosome 1 of 6KO. R-values were determined in a 22 CpG site window, positive r-values are shown in blue, negative ones in orange. Examples of local correlations are shown in Supplementary Fig. 9.
