Table 1 Characteristics of study participants (n = 1206)
From: G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults
Characteristics | Mean (SD) or n (%) |
|---|---|
Age at death baseline, years, Mean (SD) | 89.6 (6.6) |
Women, n (%) | 820 (68.0) |
Education, years, Mean (SD) | 16.2 (3.5) |
White non-Hispanic, n (%) | 1167 (96.8) |
Mini Mental State Examination score, Mean (SD) | 20.8 (9.2) |
Alzheimer’s dementia, n (%) | 507 (42.0) |
Estrogen-related medications | |
Estrogens, n (%) | 91 (7.6) |
Selective estrogen receptor modulators, n (%) | 72 (6.0) |
Aromatase inhibitors, n (%) | 23 (1.9) |
Pathological diagnosis of Alzheimer’s disease, n (%) | 775 (64.3) |
Modified Thal Amyloid-β score | |
A0, n (%) | 201 (16.7) |
A1, n (%) | 206 (17.1) |
A2, n (%) | 348 (28.9) |
A3, n (%) | 451 (37.4) |
Braak stages of neurofibrillary tangles | |
0–II, n (%) | 201 (16.7) |
III, n (%) | 300 (24.9) |
IV, n (%) | 396 (32.8) |
V–VI, n (%) | 309 (25.6) |
Global burden of amyloid-β and tau tangles | |
Square root of amyloid-β load, Mean (SD) | 1.6 (1.2) |
Square root of tau tangle density, Mean (SD) | 1.6 (1.3) |
