Fig. 8: Effect of the MSUS paradigm on beta diversity metrics of F1, F2, and F3 mice microbiota.
From: Transgenerational effects of early life stress on the fecal microbiota in mice
Comparison of MSUS versus control mice. Visualization as principal correspondence analysis of (a−c) binary (microbial composition) and (d−f) weighted Jaccard index (microbial structure). Small symbols display aggregated microbiota per cage, large symbols display centroids, and ellipses indicate 95% of confidence intervals. Microbial beta diversity of 30-week-old mice is depicted for (a, d) F1 and (c, f) F3, and microbial beta diversity of 28-week-old mice is depicted for (b, e) F2. g Heatmap of R2 for comparison between MSUS and control across different generations. Significance was calculated using PERMANOVA including FDR correction. Number of animals per group are stated in Supplementary Table 4. Comparisons of different dispersions between MSUS and controls at different time points are listed in Supplementary Table 3. ns: not significant; *p < 0.05; **p < 0.01.
