Fig. 4: SNPs on interface in CytoSIP.
From: CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors
CKs are colored in yellow and CKRs are colored in light gray. Heavy chain and Light chain of antibody are colored in magenta and lavender accordingly. Missense SNPs are labeled and colored in red on the CK-CKR interface. a The 16 SNPs found on the interaction interface of TNFA-TNFR1A or TNFA-TNFR1B mapped onto a representative TNFA structure (PDB ID: 7KPB); b The structure of IL-1β in complexed with gevokizumab with epitope and paratope shown in surface representation (PDB ID: 4G6M); c Mutants E96A, K97A, and Q116E marked on the epitopes of IL-1β with gevokizumab (PDB ID: 4G6M).
