Fig. 6: The infrastructure of the CytoSIP website.
From: CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors
Three types of queries can be input by users: Protein, Gene, and Disease. The user can also browse all available gene IDs, rsIDs, CK-CKR pairs, drugs, and antibodies. A protein page provides a list of PDB structures. Clicking on one structure leads to the same page as querying by that PDB ID, which shows the complexes architecture of the entry. From the protein page, a user can select and show the details of different categories of interfaces including interaction interfaces, targeted interfaces, epitopes, metal binding sites, and SNP. The list of different interactions and complexes can be downloaded from the protein pages or the complex pages. From the disease entry page, a user can select and display disease-correlated CK/CKR and SNP and the CK-CKR pairs involving SNPs.
