Fig. 7: Comprehensive structure in CytoSIP.
From: CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors
TNFA is used as an example for illustration. The longest segment of TNFA is selected as the representative structure for the alignment of all relevant interfaces to comparatively analyze the relative position of each interface on the structure. a Representative structure is colored in yellow, with the exception of its interaction interface colored in gray, the front and back view (horizontal flipped of 180 degrees) are shown; b Representative structure is colored in yellow, with drug surface colored in green, epitope colored in blue and metal binding sites colored in pink, the front and back view (horizontal flipped of 180 degrees) are shown; c TNFA sequence is shown alongside with interaction interface (gold strips), drug targeting surface (green strips), epitopes (blue strips) and metal binding sites (pink strips) (PDB ID: 1M4C).
