Table. 1 Data statistics in CytoSIP

From: CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors

Number of occurrence

CK

CKR

Key features in CytoSIP

Seq.ID. ≥95%

Seq.ID. <95%

Seq.ID. ≥95%

Seq.ID. <95%

SNP

2853

2982

Interaction interfaces

(2a) CK-CKR, CK-CK, CKR-CKR interaction interfaces

48109

63,004

(2b) Epitopes

1537

10,940

1101

18,873

(2c) Targeted surfaces

Small molecules

2359

35,737

3726

107,026

Metals

115

1719

122

2711

Phenotypes

7167

4746

  1. Identity refers to the similarity to the CK or CKR structure we selected. The CK-CKR interaction interface uses only structures with sequence identity >95%, while the epitopes, targeted surface for small molecules and metals also use structures with sequence identity <95%. SNPs in CytoSIP consist of missense mutations. Epitopes on CK or CKR feature interactions with antibodies such as monoclonal antibodies or nanobodies. Targeted surfaces on CK or CKR feature interactions with small molecules or drugs. Phenotype data include diseases that are known to associate with at least one CK or CKR.
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