Fig. 1: Copy number (CN) variation in lipomatous tumors with 12q gain. | Communications Biology

Fig. 1: Copy number (CN) variation in lipomatous tumors with 12q gain.

From: MDM2 amplification in rod-shaped chromosomes provides clues to early stages of circularized gene amplification in liposarcoma

Fig. 1

Distribution and frequency plots of CN gain in (a) Chr12 and (b) Chr1 from bulk DNA. Fluorescence in situ hybridization on metaphase spreads from c Case 10c, d Case 17 and e Case 18 shows that also low-level gained segments (green signals; MDM2 signals in red) are included in the ring chromosomes, as well as in the two normal homologues. Also, Case 17 (d) highlights the interchangeability between ring and rod-shaped chromosomes.

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