Fig. 5: Gene expression profiles in lipomatous tumors with 12q gain at RNA-sequencing (RNA-seq) and quantitative real-time PCR (qRT-PCR). | Communications Biology

Fig. 5: Gene expression profiles in lipomatous tumors with 12q gain at RNA-sequencing (RNA-seq) and quantitative real-time PCR (qRT-PCR).

From: MDM2 amplification in rod-shaped chromosomes provides clues to early stages of circularized gene amplification in liposarcoma

Fig. 5

a Unsupervised heatmap showing clustering of cases from Group A and B compared to control tissue/tumors (normal fat/lipoma). Box plots at RNA-seq showing expression levels of (b) CDK4, c MDM2, d HMGA2, and at qRT-PCR (e, left) HMGA2 ex1-2; (e, right) HMGA2 ex4-5. Normal fat (n = 6), Lipoma (n = 8), rod-shaped (n = 7, Cases 1–7), ring (n = 13, Cases 8–21).

Back to article page