Fig. 3: Effects of Mito-PEG5-ATO on the bacterial l-dopa consumptions. | Communications Biology

Fig. 3: Effects of Mito-PEG5-ATO on the bacterial l-dopa consumptions.

From: Mitigating gut microbial degradation of levodopa and enhancing brain dopamine: Implications in Parkinson’s disease

Fig. 3

E. faecalis was treated with Mito-PEG5-ATO as indicated in presence of l-dopa (1 mM). The effects of Mito-PEG5-ATO on the proliferation (a) were monitored at OD600 for 6 h and culture media were collected at indicated time points for l-dopa and dopamine measurements. High-performance liquid chromatography traces of representatives’ samples and standards are shown in (b). The effects of Mito-PEG5-ATO on l-dopa consumption (c) and dopamine formation (d) were shown in panels (c) and (d), respectively. Statistical significance was determined using a Student’s t test. *P < 0.05 or **P < 0.01 vs control group at each collection time point. Data shown are the mean ± SD, n = 3.

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