Table 1 Effect of mitochondria-targeted analogs on minimal inhibitory concentrations in gram negative and positive bacteria
Minimal inhibitory concentrations (μM) | ||||||
|---|---|---|---|---|---|---|
S. aureus | B. subtilis | E. faecium | E. faecalis | E. coli BL21 | P. aerug PA01 | |
HNK | 32 | 64 | 64 | 64 | NA | NA |
Mito-ortho-HNK | 1 | 1 | 0.5 | 2 | NA | NA |
Decyl-HNK | NA | NA | NA | NA | 16 | 32 |
Mito10-ATO | 16 | 4 | 8 | 8 | 64 | 64 |
Mito-PEG2-ATO | 1 | 1 | 1 | 1 | 4 | 8 |
Mito-PEG4-ATO | 1 | 1 | 1 | 1 | 4 | 8 |
Mito-PEG5-ATO | 1 | 1 | 1 | 1 | 8 | 16 |
Mito-PEG9-ATO | 2 | 2 | 2 | 4 | 8 | 16 |
