Fig. 1: Combination analysis of metabolomic and proteomic data showed T cell activation causes rewiring of the intracellular metabolism. | Communications Biology

Fig. 1: Combination analysis of metabolomic and proteomic data showed T cell activation causes rewiring of the intracellular metabolism.

From: The integration of metabolic and proteomic data uncovers an augmentation of the sphingolipid biosynthesis pathway during T-cell differentiation

Fig. 1

a, Overview of the experimental design. b and c, Heatmap depict the metabolites or protein expression related to glycolysis (b) or TCA cycle (c) in naïve CD4+, Th0, Th1, Th2, Th17, and iTreg cells. d, The relative ratio of β-Alanine was shown here. e, Heatmap depict the protein expression related to FA biosynthesis in naïve CD4+, Th0, Th1, Th2, Th17, and iTregs cells. f, The ratio of fatty acid species detected by lipidomics analysis was shown. g, Heatmap depict the levels of fatty acid in naïve CD4+, Th0, Th1, Th2, Th17, and iTregs cells. Four biological replicate was prepared for metabolomics and proteomics analysis. The source data for the figures is provided in Supplementary Data 1 and Supplementary Data 2.

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