Fig. 2: The intracellular lipid metabolism was largely changed by TCR stimulation. | Communications Biology

Fig. 2: The intracellular lipid metabolism was largely changed by TCR stimulation.

From: The integration of metabolic and proteomic data uncovers an augmentation of the sphingolipid biosynthesis pathway during T-cell differentiation

Fig. 2

a, The number of detected lipid species by lipidomics analysis was shown. b, Spider chart depicts the changes in total amounts of each lipid group compared to naïve CD4+ T cells. c, Heatmap depict the levels of each lipid species in Th0, Th1, Th2, Th17, and iTregs cells compared to naïve CD4+ T cells. d, The number of differentially expressed lipid species was shown. e, PCA depicts lipid profiles of naïve CD4+, Th0, Th1, Th2, Th17, and iTregs cells. f-k Bar plots showed that the ratio of total amounts of each lipid group (f), cholesterol (g), glycerol lipid (h), phospholipid (i), lysophospholipid (j), or sphingolipid (k). Four biological replicate was prepared for metabolomics analysis. The source data for the figures is provided in Supplementary Data 1 and Supplementary Data 2.

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