Fig. 3: Detail of the dimeric C3b-albicin binding interface.
From: Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM
a Cryo-EM map obtained after localized refinement. Density corresponding to two symmetrically arranged albicin molecules (green and wheat) contact sites on the α-chain (purple in monomer A) and β-chains (blue) of C3b. Each inhibitor also contacts a site on the second monomer. b Map in panel A rotated ~80° around the axis shown. c Ribbon diagram showing details of the α1-α2 face of albicin (green) contacting the MG7 domain and αNT (purple) of monomer A. Side chains observable in the map are shown in the expanded figure as sticks with oxygen colored red and nitrogen blue. d Ribbon diagram of dimeric C3bB-albicin highlighting the interface of albicin (green) with MG7 of monomer B (gray). Side chains are shown in the expanded figure as in panel c.
