Fig. 5: The albicin-FBb interface and a summary of albicin interactions with C3b and C3bBb.
From: Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM
a Surface representation of the C3bBb-albicin dimeric model showing interaction with C3b (β-chain in blue and α-chain in purple) and FBb (vWA domain in blue). b Ribbon diagram showing albicin FBb (vWA) interface region colored as in panel a. c Surface representation C3b dimer model (albicin and FBb removed) to show albicin-C3b interaction surfaces colored by C3b chain (yellow, β-chain, monomer A; red, α-chain, monomer A; green, α-chain, monomer B). d Model surface of C3bBb dimer with albicin removed to show FBb albicin interface colored in cyan. e Amino acid sequence of albicin with C3bBb-interacting residues colored as in panels c and d. Residues interacting with multiple chains are shown in a second row of sequence. f Ribbon diagram of albicin with residues colored by interaction site on C3bBb (NT N-terminus, CT C-terminus) in the coloring of panels c and d.
