Fig. 3: The reduced SCFAs production from the microbiome in fasted Pcca-/-(A138T) mice.

a Plasma collected from the portal vein for SCFAs (short-chain fatty acids) analysis. b–f Levels of propionate, acetate, butyrate, pentanoate, and hexanoate in portal vein plasma from both fed and fasted (23-h fasting) Pcca-/-(A138T) mice. g Metabolic alterations in portal vein plasma of fasted (23-h fasting) Pcca-/-(A138T) mice vs fed Pcca-/-(A138T) mice. N = 5 per group. The error bar represents the SE. *, **, and **** indicate p values less than 0.01, 0.005, and 0.001, respectively.