Fig. 4: Increased BCAT activity in fasted Pcca-/-(A138T) mice. | Communications Biology

Fig. 4: Increased BCAT activity in fasted Pcca-/-(A138T) mice.

From: Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to Pcca mutation

Fig. 4

a The scheme of 15N transfer from [15N, 13C5]valine to glutamate, leucine, and isoleucine via BCAT (branched-chain amino acid transferase). M1, M5, and M6 denote the presence of 1, 5, and 6 heavy atoms, respectively, within a molecule. b–d Labeling of M1 glutamate, M1 isoleucine, and M1 leucine in the plasma of both fed and fasted (23-h fasting) Pcca-/-(A138T) mice. e BCAT activity in Quad. N = 5 per group. The error bar represents the SE. *, **, ***, and **** indicate p values less than 0.05, 0.01, 0.005, and 0.001, respectively.

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