Fig. 5: Structural comparison of hABCB6^core and Atm transporters.

a Close-up view of the substrate-binding sites of hABCB6^core and AtAtm3 transporters, viewed from within the plane of the membrane. The hABCB6^core and AtAtm3 structures are colored blue and light orange, respectively. Bound substrates are depicted as empty black (for the Cd(II):GSH complex in hABCB6^core) and orange (for GSSG in AtAtm3) sticks, respectively. The residue number in parentheses indicates the equivalent residues in AtAtm3. b–d Close-up view of the GSH- (b), GSSG- (c), and mercury Hg(II):GSH- (d) binding sites of NaAtm1 superimposed on the hABCB6^core structure. The NaAtm3 structures and the bound substrates are colored light pink and pink, respectively.