Fig. 3: Virulence assay.
From: Sirtuin E deacetylase is required for full virulence of Aspergillus fumigatus
A Survival curve of A. fumigatus sirtuin mutant strains using Galleria mellonella model. The graph represents the average of three independent replicates using 10 larvae for each experiment. Significant differences were observed by using a two-way ANOVA *p < 0.05. B Survival curve of WT, ∆sirE, sirEH260Y, and ∆sirE::sirE complemented strains in female BALB/c mice (n = 10). The statistical significance of comparative survival values was calculated by the Prism statistical analysis package by using Log-rank (Mantel–Cox) Test and Gehan–Brestow–Wilcoxon tests. C Body weight variation of infected animals with the different A. fumigatus strains. D Clinical Disease Score of animals during the course of infection. For all variables, normal distribution and homogeneous variance were tested. The differences observed were considered significant when p < 0.05.
