Fig. 7: Model to depict nuclear architecture reorganization upon T lymphocyte activation. | Communications Biology

Fig. 7: Model to depict nuclear architecture reorganization upon T lymphocyte activation.

From: Super-resolution imaging of T lymphocyte activation reveals chromatin decondensation and disrupted nuclear envelope

Fig. 7

The proposed model illustrates the T cell undergoes chromatin de-condensation with increased accessibility to transcription and replication factories, nuclear envelope disruption, and the release of nuclear DNA into the cytoplasm upon T lymphocyte activation. It further illustrates the impact of metabolic activity in T cell activation, showing that metabolic inhibition leads to reduced activation and limited release of cytosolic DNA. In the visualization, nuclear DNA is represented in fire colors, while cytosolic DNA is colored in orange hot. Some elements of the figure were created with BioRender under a paid academic license.

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