Fig. 3: Analysis of myeloid cell subsets in healthy and DSS-induced UC. | Communications Biology

Fig. 3: Analysis of myeloid cell subsets in healthy and DSS-induced UC.

From: Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis

Fig. 3

a UMAP plot of scRNA-seq data for myeloid cell clusters in HC (n = 3), AC (n = 3), and CC (n = 4). b Bar plot showing cell type enrichment analysis. c Dot blot showing expression of DEGs for M1 macrophages in HC, AC, and CC. d Violin plots of Il1b expression in heterogenous polarized macrophages in AC, CC, and HC. e Western blotting result showing the IL-1β protein level expression in macrophages and colon tissue lysates. f Functional annotation enrichment analyses of upregulated genes in AC and CC. The uncropped/unedited blot images were added in the Supplementary Information (Supplementary Fig. S5).

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