Fig. 2: Temporal organization of differentially expressed genes (DEGs) between liver and kidney.
From: Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
a The pie chart displays the proportion and number of three classes of differentially expressed genes (DEGs). Among all DEGs, 35% are circadian-affected, 28% are constitutive, and 35% are temporal DEGs. b Expression abundance comparison among the three classes of DEGs. P-values were determined by Wilcoxon rank sum test. Error bars are the 95% confidence interval, the bottom and top of the box are the 25th and 75th percentiles in boxplot. c Differential transcription factors (TFs) potentially binding to distinct DEGs. Top TFs are indicated in each panel. The Venn diagram shows the number of TFs identified in overlap. d Functional annotation of the three DEG classes. Circadian-affected DEGs are enriched in metabolic functions, while other DEGs are associated with distinct biological pathways. Both enrichment odds ratio and significant level (P) are displayed. e Enrichment analysis of metabolic diseases for circadian-affected, constitutive, and temporal DEGs. + indicates significantly overrepresented, and - indicates significantly underrepresented. Different colors indicate odds ratios.
